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目的:评价不同艾滋病流行区实施母婴阻断措施的工作效率,为制定不同流行区域的干预策略提供理论依据。方法:采用成本效果和成本效用分析方法评价2008~2010年新疆维吾尔自治区2个艾滋病高流行区(A区和B区)和1个中流行区(C区)实施母婴传播阻断措施的工作效率,并整理分析相关数据。结果:2008~2010年3个地区实施母婴阻断干预措施直接避免感染人数分别为84名、68名和22名,终止妊娠避免感染的费用分别为7 677.61元、10 774.03元和26 391.53元,药物阻断避免感染的费用分别为14 331.21元、17 364.10元和27 321.12元,避免直接经济损失分别为18 373 559元、15 179 698元和5 140 299元;直接避免减少伤残调整生命年(DALY)损失分别为1 723.08健康人年、1 432.44健康人年和477.48健康人年。结论:在艾滋病高流行区实施母婴传播阻断措施的经济学效益高于中流行区,终止妊娠措施的经济学效益高于抗病毒治疗措施,针对艾滋病不同流行区域应实施不同防治重点组合策略。
OBJECTIVE: To evaluate the efficiency of maternal-child block in different AIDS endemic areas and provide theoretical basis for the formulation of intervention strategies in different endemic areas. Methods: Cost-effectiveness and cost-effectiveness analysis were used to evaluate the implementation of maternal-child transmission interruption measures in two AIDS-related high-endemic areas (A and B) and one endemic (C) in Xinjiang Uygur Autonomous Region from 2008 to 2010 Efficiency, and organize the analysis of relevant data. Results: The number of direct avoidance of maternal and child block intervention in 3 districts from 2008 to 2010 were 84, 68 and 22 respectively. The cost of avoiding pregnancy was 7 677.61 yuan, 10 774.03 yuan and 26 391.53 yuan respectively, The cost of blocking drugs to prevent infection was 14 331.21 yuan, 17 364.10 yuan and 27 321.12 yuan respectively, with the direct economic losses of 18 373 559 yuan, 15 179 698 yuan and 5 140 299 yuan avoided respectively. The direct reduction of disability-adjusted life years (DALY) losses were respectively 1 723.08 healthy years, 1 432.44 healthy years and 477.48 healthy years. Conclusion: The economic benefit of implementing maternal-child transmission interruption in AIDS-endemic areas is higher than that in endemic areas. The economic benefits of termination of pregnancy measures are higher than those of antiviral treatment. Different key prevention and treatment strategies should be implemented in different endemic areas of AIDS .