论文部分内容阅读
目的:观察纳络酮在小鼠急性有机磷农药中毒抢救中的作用。方法:60只健康小白鼠随机分为三组,A组腹腔注射生理盐水(0.5ml/只);B组腹腔注射阿托品(0.3ml/只)和解磷定(0.1ml/只);C组腹腔注射阿托品(0.3ml/只)、解磷定(0.1ml/只)和纳络酮(0.03ml/只))。三组小鼠腹腔注射后分别用敌敌畏灌胃,使之中毒,并计数其死亡数。结果:A组小鼠均死亡。B组小鼠死亡8只,存活12只。C组小鼠死亡2只,存活18只。B组、C组经统计学分析,有显著性差异(P<0.05)。结论:纳络酮治疗急性有机磷农药中毒,可改善心肺功能,减少并发症,降低死亡率,且使用安全。
Objective: To observe the role of naloxone in the rescue of acute organophosphorus pesticide poisoning in mice. Methods: Sixty healthy mice were randomly divided into three groups: group A received intraperitoneal injection of saline (0.5ml / mouse); group B received intraperitoneal injection of atropine (0.3ml / Injection of atropine (0.3ml / only), phosphate solution (0.1ml / only) and naloxone (0.03ml / only)). After intraperitoneal injection of three groups of mice were dosed with dichlorvos, so that poisoning, and count the number of deaths. Results: A group of mice died. B group of mice died 8, survived 12. Two mice in group C died and 18 survived. B group, C group by statistical analysis, there was a significant difference (P <0.05). Conclusion: Naloxone treatment of acute organophosphorus pesticide poisoning can improve cardiopulmonary function, reduce complications, reduce mortality, and safe to use.