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内毒素是革兰氏阴性细菌细胞壁结构中的脂多醣(Lipopolysacharide,LPS)由类脂A,R-核心多醣及O抗原三部分组成,具有广泛而复杂的生物学活性,它参与或激发多种重要的临床病理过程,如休克、弥漫性血管内凝血等,肝脏特别是枯否氏细胞在对内毒素的清除和解毒中起主要作用,肝脏受损时来源于肠道的内毒素可进入体循环造成内毒素血症,内毒素的蓄积又可反过来损害肝脏或/和产生肝外病变,现就谈几点有关问题:
Endotoxin is a Gram-negative bacterial cell wall structure of lipopolysaccharide (Lipopolysacharide, LPS) by the lipid A, R-core polysaccharide and O antigen three parts, with a wide range of complex biological activity, which involved in or stimulate a variety of Important clinical and pathological processes, such as shock, diffuse intravascular coagulation, liver, especially Kupffer cells play a major role in endotoxin removal and detoxification, liver damage from the intestinal endotoxin can enter the systemic circulation Resulting in endotoxemia, endotoxin accumulation can in turn damage the liver or / and extrahepatic lesions, now talk about the relevant issues: