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目的探讨国产人胶原狗声带注射的组织学转归及其在矫治声门闭合不全中的应用价值和前景。方法实验动物分为４组，Ａ组２只分别注射人胶原和自体脂肪矫正左侧声带麻痹引起的声门闭合不全，并对治疗效果进行主、客观观察，术后５个月取材，透射电镜观察。Ｂ、Ｃ、Ｄ组９只狗（每组３只）于右侧声带注入人胶原、左侧声带注入自体脂肪各０．３ｍｌ，分别于术后１、３、５个月取材并观察其组织学变化和体积变化。结果自体脂肪能在声带组织中存活，但吸收率很高，１、３、５个月体积平均减少速度为３８．５１％，疗效不能持久。人胶原易于注射，组织相容性好，并能被宿主成纤维细胞和血管移生，同时伴有宿主胶原的再生，显示出最终被宿主组织完全取代的趋势，１～５个月体积平均减少速度为０．６５％。矫治效果长期稳定。结论自体脂肪应用有局限性，只能作为短期的声带植入材料；人胶原可用于各种原因所致声门闭合不全的长期矫治材料，具有良好的应用前景。
Objective To investigate the clinical significance of vocal cord injection of domestic human collagens and its value in the treatment of glottis insufficiency. Methods The experimental animals were divided into 4 groups. A group 2 were injected human collagen and autologous fat-corrected left vocal cord paralysis caused by glottis insufficiency, and the treatment effect of the main and objective observation, 5 months after surgery, transmission electron microscopy Observed. Group B, C and D, 9 dogs (3 in each group) were infused with human collagen on the right vocal cords and 0.3 ml of autologous fat on the left vocal cords. The tissues were harvested at 1, 3, and 5 months after operation Learning change and volume change. Results Autologous fat survived in vocal cord tissues, but the absorption rate was high. The average reduction rate of 1, 3 and 5 months volume was 38.51%. The curative effect could not be sustained. Human collagen is easy to inject and has good histocompatibility and is capable of being transplanted into host fibroblasts and blood vessels with the regeneration of host collagen, which shows a tendency to be completely replaced by the host tissue with an average reduction of 1 to 5 months in volume The speed is 0.65%. Long-term correction effect of stability. Conclusion There are limitations to the application of autologous fat, which can only serve as short-term vocal cord implants. Human collagen can be used as a long-term orthodontic material for glottis insufficiency due to various causes and has good application prospects.