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目的:探讨纳洛酮联合高压氧治疗重度新生儿缺氧缺血性脑病的临床疗效。方法:以2004年1月～2006年12月该院收治的79例重度HIE为治疗组,以2001年1月～2003年12月收治的80例HIE患儿为对照组。两组均采用相同的综合治疗措施,治疗组在此基础上加用纳洛酮和高压氧治疗。观察两组临床症状改变、NBNA评分及病死率。结果:治疗组临床症状改变、NBNA评分及病死率与对照组相比均有统计学差异(P<0.05)。结论:纳洛酮联合高压氧治疗重度新生儿缺氧缺血性脑病能有效改善症状,降低病死率,减少致残率。
Objective: To investigate the clinical effect of naloxone combined with hyperbaric oxygen on severe neonatal hypoxic-ischemic encephalopathy. Methods: From January 2004 to December 2006, 79 cases of severe HIE admitted to our hospital were treated, and 80 HIE children treated from January 2001 to December 2003 were selected as the control group. The same combination of treatment measures was used in both groups, on the basis of which naloxone and hyperbaric oxygen were added to the treatment group. The changes of clinical symptoms, NBNA score and mortality were observed. Results: The clinical symptoms, NBNA score and mortality in the treatment group were significantly different from those in the control group (P <0.05). Conclusion: Naloxone and hyperbaric oxygen therapy for severe neonatal hypoxic-ischemic encephalopathy can effectively improve symptoms, reduce mortality and reduce morbidity.