论文部分内容阅读
采用免疫组织化学ＰＡＰ法，测定１０５例大肠癌癌组织ＥＲ、ＰＲ表达情况和预后之间关系。结果发现大肠癌ＥＲ、ＰＲ阳性率分别为３４．３％（３６／１０５）和２１．０％（２２／１０５）。大肠癌ＥＲ、ＰＲＲ性与病人性别、年龄、肿瘤部位、大小、浸润深度无关（Ｐ＞０．０５）．而与大肠癌的组织分化程度、Ｄｕｋｅｓ分期、淋巴结转移相关（Ｐ＜０．０５）。ＥＲ（＋）ＰＲ（＋）和ＥＲ（＋）ＰＲ（－）者（９５．５％．９０．９％，８６．４％：１００．０％，７８．６％，７１．４％）的一、三、五年生存率均显著高于ＥＲ（一）ＰＲ（－）者（７１．０％，４４．９％，３７．７％）（Ｐ＜０．０５）。本实验证实大肠癌可能是一种激素依赖性肿瘤·对其激素受体的检测有可能成为判断大肠癌预后和选择内分泌治疗的重要标志之一。
Immunohistochemical PAP method was used to determine the relationship between ER and PR expression and prognosis in 105 cases of colorectal cancer. The results showed that the positive rates of ER and PR in colorectal cancer were 34.3% (36/105) and 21.0% (22/105), respectively. The ER, PRR of colorectal cancer was not related to the patient’s gender, age, tumor location, size, depth of invasion (P>0.05). It was associated with the degree of histological differentiation, Dukes stage, and lymph node metastasis (P<0.05). ER (+) PR (+) and ER (+) PR (-) (95.5%.90.9%, 86.4%: 100.0%, 78.6%, 71.4%) The one-, three-, and five-year survival rates were all significantly higher than those of ER (I) PR (-) (71.0%, 44.9%, 37.7%) (P < 0.05). This experiment confirmed that colorectal cancer may be a hormone-dependent tumor. The detection of its hormone receptor may become one of the important markers for judging the prognosis of colorectal cancer and selecting endocrine therapy.