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在观察卵巢癌的单核细胞和巨噬细胞活动前,作者观察了外周血单核细胞在试管内转化成巨噬细胞的能力,并研究了调节这一过程的因素。外周血单核细胞和肿瘤内巨噬细胞都是免疫系统的一部分,但至今尚未对卵巢癌进行研究。为确定它与免疫机理和免疫治疗,特别是在免疫物质刺激后可能出现的变化间的关系,有必要作一观察。癌瘤患者中已经发现一些单核细胞功能试验异常。与正常对照相比,恶性黑色素瘤和乳癌患者缺乏单核细胞成熟,越是晚期肿瘤,这种缺陷越明显。静脉或皮内注射小棒状杆菌,可使单核细胞成熟为巨噬细胞活动
Before observing the activity of monocytes and macrophages in ovarian cancer, the authors observed the ability of peripheral blood mononuclear cells to transform into macrophages in vitro and investigated the factors that regulate this process. Both peripheral blood mononuclear cells and intra-tumor macrophages are part of the immune system, but so far ovarian cancer has not been studied. In order to determine its relationship with the immunological mechanisms and immunotherapy, and in particular with possible changes after immunization, it is necessary to make an observation. Some patients with cancer have found abnormal monocyte function tests. Compared with normal controls, malignant melanoma and breast cancer patients lack monocyte maturation, the more advanced tumors, the more obvious the defect. Corynebacterium parvum injected intravenously or intradermally, monocytes can mature into macrophage activity