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目的探讨胃癌患者血清CD27和CD27L的表达与胃癌及病理指标的关系。方法应用ELISA方法检测42例胃癌患者血清标本中CD27和CD27L的表达,与40例同期正常对照者的血清标本作对比分析。同时采用单因素方差分析和Spearman相关分析探寻CD27和CD27L的表达浓度与胃癌病理类型、病理分期及TNM分期的关系。结果胃癌患者血清CD27和CD27L的表达显著低于正常对照者(P<0.05)。在胃癌患者中,除血清CD27L的表达在病理分期Ⅱ期和Ⅲ期之间(P=0.017)有显著差异以及血清CD27的表达在N1和N2之间(P=0.022)有显著差异外,其余指标在不同病理类型、分期及TNM分期之间无显著差异。Spearman相关分析显示,CD27和CD27L的表达与病理类型、分期及TNM分期无显著相关性。结论血清CD27和CD27L表达与胃癌的发病密切相关,可作为协同判断胃癌发病的指标。
Objective To investigate the relationship between the expression of CD27 and CD27L in gastric cancer and gastric cancer and their pathological parameters. Methods The expression of CD27 and CD27L in serum of 42 patients with gastric cancer was detected by ELISA. Serum samples from 40 normal controls were compared. At the same time, using single factor analysis of variance and Spearman correlation analysis to explore the CD27 and CD27L expression concentration and gastric cancer pathology, pathological staging and TNM staging relationship. Results The expressions of CD27 and CD27L in gastric cancer patients were significantly lower than those in normal controls (P <0.05). In gastric cancer patients, there was a significant difference in serum CD27L expression between stage II and III (P = 0.017) and serum CD27 expression between N1 and N2 (P = 0.022) There was no significant difference in the indexes between different pathological types, staging and TNM staging. Spearman correlation analysis showed that CD27 and CD27L expression and pathological type, stage and TNM staging no significant correlation. Conclusions Serum CD27 and CD27L expressions are closely related to the pathogenesis of gastric cancer and can be used as an index to determine the incidence of gastric cancer.