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据报告,L-硝苯啶能有效地抑制凝血和血小板聚集。方法 8例健康男性,23.3±0.5岁,平均吸烟4.0±1.4年(至少2年),每天20支以上;另8例健康男性,23.3±0.6岁,不吸烟。至少2周内未服任何药物。口服缓释型钙拮抗剂L-硝苯啶20mg,每日2次共10日。结果服药10日后,吸烟组舒张压由10.4±0.36降至8.88±0.37 kPa(P<0.02),不吸烟组则由9.79±0.53升至11.15±0.64 kPa(与吸烟组相比p<0.01);
It has been reported that L-nifedipine effectively inhibits coagulation and platelet aggregation. Methods Eight healthy men, 23.3 ± 0.5 years, with an average of 4.0 ± 1.4 years (at least 2 years), more than 20 per day. The other 8 healthy men, 23.3 ± 0.6 years old, did not smoke. Not taking any medication for at least 2 weeks. Oral slow-release calcium antagonist L-nifedipine 20mg, 2 times a day for a total of 10 days. Results After 10 days of treatment, the diastolic blood pressure of smoking group decreased from 10.4 ± 0.36 to 8.88 ± 0.37 kPa (P <0.02), while the non - smoking group increased from 9.79 ± 0.53 to 11.15 ± 0.64 kPa (p <0.01 compared with smoking group).