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多项研究已证实骨唾液酸蛋白(BSP)与乳腺癌骨转移具有相关性,而目前研究的热点是BSP诱导乳腺癌骨转移的具体作用机制及参与BSP基因表达调控的因子种类,这将为今后研究治疗骨转移相应靶向药物提供直接理论依据。同时将BSP与其他骨代谢指标如OPN、TRACP5b、NTx、PTHrP等联合检测可提高乳癌骨转移高风险人群筛选的精确性,并且这些因子可以作为乳腺癌的独立预后因素。
Several studies have demonstrated that bone sialoprotein (BSP) is associated with bone metastasis in breast cancer. The current research focuses on the specific mechanism of BSP-induced bone metastasis of breast cancer and the types of factors involved in the regulation of BSP gene expression, which will be In the future, it will provide a direct theoretical basis for the research of corresponding targeted drugs for treating bone metastasis. BSP and other bone metabolic markers such as OPN, TRACP5b, NTx, PTHrP and other joint detection can improve the accuracy of screening of patients with high risk of bone metastasis of breast cancer, and these factors can be used as an independent prognostic factor for breast cancer.