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甲、酶自杀底物的临床应用一、酶的自杀底物——专一性靶酶的基于机制的失活剂酶在进行酶促反应时,必须先形成酶-底物复合体,然后由复合体分解成最终产物:酶有专一性,故与它所催化的底物之间有较高的亲和力。如果酶遇到了不相平的非底物的其它化合物,与之没有亲和力,也不会去结合。除了酶的底物以外,能与酶结合的物质还有抑制剂和失活剂两类。抑制剂与酶的结合一般是可逆的,而且有的抑制剂与酶的亲和力比底物还大。失活剂一般对蛋白质起修饰和变性
A, the clinical application of enzyme suicide substrate First, the enzyme of suicide substrate - a specific target enzyme based on the mechanism of inactivation enzymes in the enzymatic reaction, we must first form enzyme - substrate complex, and then by The complex breaks down into the final product: the enzyme is specific and therefore has a high affinity for the substrate it catalyzes. If the enzyme encounters an out-of-phase, non-substrate compound, it has no affinity for it and will not bind. In addition to the substrate of the enzyme, there are two classes of inhibitors and inactivators that can bind to enzymes. Inhibitors and enzyme binding is generally reversible, and some inhibitors and the enzyme affinity than the substrate is also large. Deactivators generally modify and denature proteins