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目的探讨婴儿期进行免疫干预对改善毛细支气管炎患儿Th1/Th2免疫紊乱和复发喘息的影响,旨在为临床医疗提供有效的理论依据。方法将47例患儿随机分为毛支观察组23例和毛支对照组24例,同时设正常对照婴儿15例,毛支观察组给予卡介苗素治疗1年,治疗前后分别对毛支观察组和毛支对照组及正常对照组用ELISA方法检测血清IL10、IL12,并随访两年。结果①毛支观察组和毛支对照组IL210明显高于正常对照组,IL12明显低于正常对照组(P<0.001)。②毛支观察组经卡介苗多糖核酸治疗后IL10明显降低,IL12明显升高。③反复喘息次数明显减少,喘息时间明显缩短。结论毛支患儿存在着Th1/Th2免疫功能紊乱,婴儿期进行免疫干预能明显改善毛支患儿Th1/Th2免疫紊乱状况,并能预防哮喘的发生、发展。
Objective To investigate the effect of immunization intervention in infancy on the improvement of Th1 / Th2 immune disorder and recurrent wheeze in children with bronchiolitis, and to provide an effective theoretical basis for clinical medical treatment. Methods A total of 47 children were randomly divided into observation group (23 cases) and control group (24 cases). Fifteen cases of normal control infant and BCG observation group were treated with BCG for one year. Before and after treatment, Serum IL10 and IL12 were detected by ELISA in the control group and the normal control group, and were followed up for two years. Results ① The IL210 in the capillary branch and the control group was significantly higher than that in the normal control group, IL12 was significantly lower than the normal control group (P <0.001). ② hair branch observation group by the BCG polysaccharide nucleic acid IL10 significantly reduced, IL12 was significantly higher. ③ significantly reduced the number of repeated breathing, wheezing significantly reduced. Conclusion There is a Th1 / Th2 immune dysfunction in children with bronchiolitis. Immune intervention in infancy can significantly improve the Th1 / Th2 immune disorder in children with bronchiolitis and prevent the occurrence and development of asthma.