人参皂苷治疗缺血性脑卒中研究进展

• 作 者: 顾玉宝 刘敬霞 王枫 刘抒雯 刘超 甘佳乐
• 机 构: 宁夏医科大学研究生院,宁夏医科大学中医学院,宁夏医科大学回医药现代化省部共建教育部重点实验室,
• 出 处: 新中医
• 发表日期: 2017年04期
• 关键词: 人参皂苷 缺血性脑卒中 作用机制 神经元坏死 缺血性损害 脑血管疾病 感觉障碍 细胞凋亡 缺血再灌注损伤 脑缺血再灌注

缺血性脑血管病是指脑部血液供血不足引起的脑组织缺血性损害,使局部血液循环所提供的氧和其它营养物质与神经元代谢需求之间骤然供应与需求不平衡,最终导致缺血中央区的神经元坏死的一类疾病,其临床表现为肢体无力、偏瘫、感觉障碍、语言障碍、视觉障碍、共济失调等~([1])。脑血管疾病是造成人类死亡的三大疾病之一,具有高发病率、高病死率、高致残率的特点,严重危害人类健康并降低患者的生存质量。缺血性脑卒中是由于大脑主要动脉的血流短暂或持久阻断所引起,

Ischemic cerebrovascular disease refers to ischemic damage of brain tissue caused by insufficiency of blood supply to the brain and causes an imbalance of supply and demand between the supply of oxygen and other nutrients provided by the local blood circulation and neuronal metabolism eventually leading to The central area of ​​ischemic neuronal necrosis of a class of diseases, the clinical manifestations of limb weakness, hemiplegia, sensory dysfunction, speech disorders, visual disorders, ataxia, etc. ~ ([1]). Cerebrovascular disease is one of the three major diseases that cause human death. It has the characteristics of high morbidity, high mortality and high morbidity, which seriously endangers human health and reduces the quality of life of patients. Ischemic stroke is caused by a transient or permanent blockage of the bloodstream in the main cerebral arteries,