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目的探讨载脂蛋白B(ApoB)与高脂血症合并非酒精性脂肪性肝病(NAFLD)的关系。方法118例高脂血症伴NAFLD组和65例糖尿病伴高脂血症及NAFLD组分别与98例单纯性高脂血症的ApoB进行对比,比较二者之间ApoB的水平及Apo-B增高的患者所占的百分比。结果高脂血症伴NAFLD组Apo-B水平为(1.28±0.38),Apo-B升高的发生率为89%,糖尿病伴高脂血症及NAFLD组Apo-B水平为(1.4±0.44),升高发生率为97%,单纯性高脂血症组(对照组)Apo-B水平为(0.83±0.15),升高发生率为20.4%。结论高脂血症伴NAFLD组和糖尿病伴高脂血症及NAFLD组的Apo-B水平明显高于对照组,差异有显著统计学意义(P<0.05)。因此apoB的水平可考虑作为高脂血症患者在肝脏影像学提示脂肪肝时的支持诊断指标之一
Objective To investigate the relationship between apolipoprotein B (ApoB) and hyperlipidemia with non-alcoholic fatty liver disease (NAFLD). Methods A total of 118 cases of hyperlipidemia with NAFLD and 65 cases of diabetes with hyperlipidemia and NAFLD were compared with 98 cases of simple hyperlipidemia ApoB, the level of ApoB and the increase of Apo-B Of patients accounted for the percentage. Results The Apo-B level was (1.28 ± 0.38) in hyperlipidemic patients with NAFLD and 89% in patients with hyperlipidemia and NAFLD (1.4 ± 0.44) , The rate of increase was 97%. The level of Apo-B in simple hyperlipidemia group (control group) was (0.83 ± 0.15) and the increase rate was 20.4%. Conclusion The Apo-B level in hyperlipidemic patients with NAFLD, diabetic hyperlipidemia and NAFLD is significantly higher than that in control group (P <0.05). Therefore, the level of apoB may be considered as one of the diagnostic criteria for hyperlipidemia when liver imaging is suggestive of fatty liver