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胰岛素样生长因子(IGF)通过其受体和结合蛋白的调节,促进细胞增殖、抑制细胞凋亡。越来越多的研究发现,IGF家族参与包括胃癌在内的许多相关肿瘤发生、发展及预后。近年来对胃癌患者血液中IGF家族进行了大量基础和临床研究的结果显示,IGF家族可能在胃癌的发生、发展及预后中起重要作用。如抑制其受体信号通路可为胃癌的综合治疗提供新靶点;IGF受体的单克隆抗体可作为胃癌的辅助治疗等。现就IGF家族在胃癌领域的最新研究进展进行综述。
Insulin-like growth factor (IGF) through its receptor and binding protein regulation, promote cell proliferation, inhibit apoptosis. More and more studies have found that the IGF family is involved in many related tumorigenesis, development and prognosis, including gastric cancer. In recent years, a large number of basic and clinical researches on IGF family in the blood of patients with gastric cancer have shown that the IGF family may play an important role in the occurrence, development and prognosis of gastric cancer. Such as inhibition of its receptor signaling pathway for the treatment of gastric cancer provide a new target; monoclonal antibody monoclonal antibody can be used as gastric cancer adjuvant therapy. Now on the IGF family in the field of gastric cancer, the latest research progress are reviewed.