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目的探讨足部恶性黑色素瘤的临床表现、诊断与治疗。方法回顾性分析我科1994年至2006年收治的21例足部恶性黑色素瘤患者。其中男性19例,女性2例,平均年龄63.8岁(42～86岁)。结果所有患者均经病理证实为足部恶性黑色素瘤。21例患者确诊后均接受了外科手术治疗,术后5例接受化疗,2例接受生物学治疗。19例随访3～41个月。2例患者分别于术后6个月及31个月死亡,其余患者目前均存活。结论目前恶性黑色素瘤仍是不能根治的疾病。足底为负重功能区,应根据手术切除后缺损的部位和范围,选择合适的皮瓣修复对足部功能恢复起着十分重要的作用。
Objective To investigate the clinical manifestations, diagnosis and treatment of foot malignant melanoma. Methods Retrospective analysis of 21 cases of foot malignant melanoma admitted to our department from 1994 to 2006. There were 19 males and 2 females, with an average age of 63.8 years (range, 42-86 years). Results All patients were pathologically confirmed as foot malignant melanoma. Twenty-one patients underwent surgical treatment after diagnosis, five patients received chemotherapy and two received biologic therapy. 19 cases were followed up for 3 to 41 months. Two patients died at 6 months and 31 months after surgery, respectively, and the remaining patients currently survived. Conclusions Malignant melanoma is still an incurable disease. Plantar weight-bearing functional area, should be based on the location and scope of surgical resection of the defect, select the appropriate skin flap repair on foot function plays a very important role.