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目的 :观察小儿病毒性心肌炎 IL- 6、IFN- γ及 Ig G亚类变化 ,进一步探讨在心肌炎发生、发展中细胞因子及 Ig G亚类的作用及其关系。方法 :采用酶联免疫吸附试验测定 47例柯萨奇 B组 (Cox B)病毒性心肌炎患儿 IL- 6、IFN- γ及 Ig G亚类水平。结果 :柯萨奇 B组 (Cox B)病毒性心肌炎患儿血清 IFN-γ、IL - 6均明显升高且呈正相关 ;Ig G1 、Ig G2 、Ig G3明显降低且 IL - 6与 Ig G1呈负相关。结论 :人血丙种球蛋白可作为 IL - 6的拮抗剂用于小儿柯萨奇 B组病毒性心肌炎的治疗
OBJECTIVE: To observe the changes of IL-6, IFN-γ and IgG subtypes in viral myocarditis in children and to further explore the roles of cytokines and IgG subtypes in the pathogenesis and progression of myocarditis. Methods: The levels of IL - 6, IFN - γ and IgG in 47 Cox B patients with viral myocarditis were determined by enzyme - linked immunosorbent assay (ELISA). Results: Serum levels of IFN - γ and IL - 6 in children with Cox B myocarditis were significantly increased and positively correlated; Ig G1, Ig G2 and Ig G3 were significantly decreased and IL - 6 and Ig G1 Negative correlation. CONCLUSION: Human blood gamma globulin can be used as an antagonist of IL - 6 in the treatment of children with Coxsackie B viral myocarditis