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目的观察参芪扶正注射液联合FOLFOX4方案治疗晚期结直肠癌的效果。方法36例患者随机分为治疗组22例和对照组14例,两组均应用FOLFOX4方案化疗,治疗组同时加用参芪扶正注射液。结果治疗组有效率为36.4%,对照组为35.7%(P>0.05);治疗组体重增加、Karnofsky评分提高均高于对照组(P<0.05);治疗组Ⅱ度以上白细胞下降发生率较对照组低(P<0.05)。结论参芪扶正注射液联合FOLFOX4方案能提高晚期大肠癌患者生活质量,具有一定的减毒增效作用。
Objective To observe the effect of Shenqi Fuzheng injection combined with FOLFOX4 regimen in the treatment of advanced colorectal cancer. Methods Thirty-six patients were randomly divided into treatment group (n = 22) and control group (n = 14). FOLFOX4 regimen was used in both groups. Shenqi Fuzheng injection was used in the treatment group. Results The effective rate was 36.4% in the treatment group and 35.7% in the control group (P> 0.05). The weight gain and Karnofsky score in the treatment group were significantly higher than those in the control group (P <0.05). The incidence of leukopenia in the treatment group was higher than that in the control group Group was lower (P <0.05). Conclusion Shenqi Fuzheng injection combined with FOLFOX4 regimen can improve the quality of life of patients with advanced colorectal cancer, with a certain attenuating synergism.