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目的探讨血浆胃肠激素ghrelin水平改变在极低出生体重早产儿喂养不耐受(FI)发生、发展中的作用。方法选择我院2013年1月至2015年4月收治的极低出生体重早产儿为研究对象,发生FI患儿为FI组,未发生FI患儿为喂养耐受(FT)组。于开始喂养前、FI发生后、治疗好转后抽取静脉血检测ghrelin水平。结果共63例患儿完成本研究,其中FI组30例、FT组33例,两组患儿胎龄、出生体重、开始喂养时间等差异无统计学意义(P>0.05)。开始喂养前FI组患儿血ghrelin水平为(16.05±1.82)μg/L,FT组为(18.01±1.77)μg/L,组间比较差异有统计学意义(P=0.003)。FI组发病后血ghrelin水平为(16.06±1.63)μg/L,与发病前比较差异无统计学意义(P=0.976)。FI组治疗好转后血ghrelin水平为(17.46±1.72)μg/L,与发病时比较差异有统计学意义(P=0.026)。结论胃肠激素ghrelin与极低出生体重早产儿FI的发生和发展具有相关性。
Objective To investigate the role of changes in plasma ghrelin level in the development and progression of feeding intolerance (FI) in very low birth weight preterm infants. Methods Fourteen patients with very low birth weight preterm infants admitted to our hospital from January 2013 to April 2015 were enrolled in this study. FI children with FI were enrolled as FI group, and no FI children were enrolled as FT group. Before the start of feeding, after FI occurred, the blood samples were collected to detect the ghrelin level after the treatment was improved. Results A total of 63 children completed the study. There were 30 cases in FI group and 33 cases in FT group. There was no significant difference in gestational age, birth weight and feeding time between the two groups (P> 0.05). The level of ghrelin in children with FI before starting feeding was (16.05 ± 1.82) μg / L and in FT group (18.01 ± 1.77) μg / L, respectively. There was significant difference between the two groups (P = 0.003). The blood ghrelin level in FI group after onset was (16.06 ± 1.63) μg / L, with no significant difference compared with before onset (P = 0.976). After treatment, the blood ghrelin level in FI group was (17.46 ± 1.72) μg / L, which was significantly different from the onset of disease (P = 0.026). Conclusion Gastrointestinal hormone ghrelin is associated with the occurrence and development of FI in very low birth weight premature infants.