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选择我院于2015年6月~2016年6月期间收治的70例T2DM患者,随机分为与对照组(30例)。给予二甲双胍片治疗,观察组(30例)二甲双胍加吡格列酮。结果观察组总有效高于对照组,(P<0.05);治疗前两组内皮素(ET)及一氧化氮(NO)水平相比无明显差异(P>0.05);治疗后观察组ET水平低于对照组,NO高于对照组(P<0.05);治疗前两组空腹血糖(FBG)、餐后2h血糖(PBG)及糖化血红蛋白(Hb A1c)无明显差异(P>0.05);治疗后两组均显著下降,且观察组下降明显(P<0.05)。结论吡格列酮联合二甲双胍疗效确切,对血管内皮功能改善有一定的作用。
Seventy patients with T2DM admitted to our hospital from June 2015 to June 2016 were randomly divided into control group (30 cases). Metformin tablets were given to patients in the observation group (30 cases) and metformin plus pioglitazone. Results The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). There was no significant difference in the levels of ET and NO between the two groups before treatment (P> 0.05) (P <0.05). Before treatment, there was no significant difference in fasting blood glucose (FBG), postprandial 2h blood glucose (PBG) and Hb A1c between the two groups (P> 0.05) After the two groups were significantly decreased, and the observation group decreased significantly (P <0.05). Conclusions Pioglitazone combined with metformin has a definite curative effect on vascular endothelial function.