A novel vitamin K_4 derivative-1,2,4-trinaphthol-acetic ester

• 出 处: 医药产业资讯
• 发表日期: 2006年14期
• 关键词: acetic vitamin derivative reactant medicines naphthalene spectrometer methanol c

A novel derivative of vitamin K4, 1, 2, 4- trinaphthol- acetic ester, is synthesized by directly reacting of2- hydroxy- 1, 4- naphthoquinone with acetic anhydride, where zinc powder is used as reductant. By examiningthe influences of reacting time, temperature and reactant ratio, the esterification conditions are optimized. The ex-perimental result shows that, the esterification yield can reach 40% with a single cycle of the simple synthetic route.

A novel derivative of vitamin K4, 1, 2, 4-trinaphthol-acetic ester, was synthesized by directly reacting of 2-hydroxy- 1, 4- naphthoquinone with acetic anhydride, where zinc powder is used as reductant. the temperature and reactant ratio, the esterification conditions are optimized. The ex-perimental result shows that the esterification yield can reach 40% with a single cycle of the simple synthetic route.