论文部分内容阅读
1931年Karolinska研究所的Von Euler和Gaddum研究乙酰胆碱的分布时,发现马脑和肠的酸性醇提取物中存在一种物质,它能促使离体兔肠收缩和使血管舒张,降低血压,那时就认定该有效成份为一种多肽物质并称之为P物质(Substance-P,简称SP,下同) 从发现到现在半个世纪过去了,国外对P物质的研究已很系统、深入国内研究的单位很少。我们从1977年开始对Sp进行研究至今整整十周年了。1982年12月由浙江省卫生厅和商业厅共同主持了技术鉴定会,1984年省卫生厅正式批文同意生产。之后,我们又进行了SP
When Von Euler and Gaddum of the Karolinska Institute in 1931 studied the distribution of acetylcholine, it was found that there was a substance present in the acidic alcoholic extract of the equine brain and intestine which stimulated intestinal contraction and vasodilation in vitro and reduced blood pressure, when It has been found that the active ingredient is a kind of polypeptide substance and is called Substance-P (Substance-P, referred to as SP, the same below) from the discovery to the present half a century later. The foreign research on Substance P has been systematically and deeply studied in China Very few units. We’ve been studying Sp for a full tenth anniversary since 1977. December 1982 by the Zhejiang Provincial Health Department and the Department of Commerce co-chaired the technical appraisal meeting, in 1984 the provincial Health Department approved the formal approval of production. After that, we conducted another SP