论文部分内容阅读
哮喘是一种常见病,平喘药在防治哮喘与呼吸道疾患引起的喘息占有重要地位,近年来对平喘药的研究颇多,迄今已有50余种,本文就其作用环节不同分述如下。一、茶碱类药茶碱类是最常用的传统平喘药,既往认为其作用为抑制磷酸二脂酶,使气道平滑肌细胞内cAMP不易分解,从而使平滑肌松弛。近年研究表明对磷酸二脂酶影响不大,其主要作用:1.平滑肌内外钙离子浓度的改变,增加细胞内cAMP含量;2.抑制前列腺素F_(2α)对平滑肌的收缩;3.促
Asthma is a common disease, antiasthmatic drugs in the prevention and treatment of asthma and respiratory diseases caused by wheezing occupy an important position in recent years, many studies on antiasthmatic agents, so far has more than 50 species, this article on the role of different points as follows . First, theophylline class Theophylline is the most commonly used traditional antiasthmatic drugs, past that its role as phosphodiesterase inhibition, airway smooth muscle cells within the cAMP difficult to break down, so that smooth muscle relaxation. Recent studies show that phosphodiesterase little effect, its main role: 1. Smooth muscle intramuscular calcium concentration changes, increase intracellular cAMP content; 2. Prostaglandin F_ (2α) inhibition of smooth muscle contraction; 3. Promote