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目的:评价氟比洛芬酯复合布托啡诺用于肝癌切除术后静脉镇痛的临床效果及安全性,并与常用的吗啡复合罗哌卡因硬膜外镇痛比较。方法:60例择期肝癌切除术患者,随机分为两组:实验组用氟比洛芬酯复合布托啡诺静脉镇痛,对照组用吗啡复合罗哌卡因硬膜外镇痛。记录术中出血量、术毕苏醒时间、术后镇痛视觉模拟评分(VA S)、首次排气时间、住院时间、镇静评分及不良反应。结果:两组术后VA S评分、术中出血量、术后首次排气时间、住院时间、及镇静评分无统计学差异(P>0.05)。实验组术毕苏醒时间延长10.3 m in,但术后不良反应少于对照组(P<0.01)。结论:氟比洛芬酯复合布托啡诺静脉镇痛可作为肝癌切除术可供选择的,安全有效的术后镇痛方法。
OBJECTIVE: To evaluate the clinical efficacy and safety of flurbiprofen axetil combined with butorphanol for intravenous analgesia after hepatectomy and to compare with the commonly used morphine combined with ropivacaine epidural analgesia. Methods: Sixty patients undergoing elective liver resection were randomly divided into two groups: experimental group treated with flurbiprofen ester combined with butorphanol intravenous analgesia, and control group received morphine combined with ropivacaine epidural analgesia. The intraoperative blood loss, postoperative awake time, postoperative pain visual analogue scale (VA S), time to first extubation, hospital stay, sedation score and adverse reactions were recorded. Results: The postoperative VA S score, intraoperative blood loss, postoperative first exhaust time, hospital stay, and sedation score had no significant difference (P> 0.05). The recovery time of experimental group was 10.3 minutes longer than that of control group (P <0.01). CONCLUSION: Flurbiprofen ester complex butorphanol intravenous analgesia can be used as a safe, effective postoperative analgesia for hepatocellular carcinoma resection.