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目的：探讨宫内膜腺癌组化、免疫组化特征及临床意义。方法：采用组化、免疫组化的方法，对其粘蛋白含量、分布及免疫阳性物的表达进行观察。结果：子宫内膜腺癌与宫颈腺癌在粘蛋白含量与分布存在着差异：子宫内膜腺癌粘蛋白含量少且以硫酸粘蛋白为主，而宫颈腺癌则含量丰富且以唾酸粘蛋白为主。波形蛋白（Ｖｉｍｅｎｔｉｎ）在宫内膜腺癌阳性表达率为７３．３％，而宫颈腺癌均阴性表达。雌激素受体（ＥＲ）、癌胚抗原（ＣＥＡ）、增殖细胞核抗原（ＰＣＮＡ）在肿瘤分类中表达无明显差异，但对预后和分级有一定意义，ＥＲ阳性者临床内分泌治疗疗效和预后较好；而ＣＥＡ对于肿瘤早期转移有一定关系。结论：组化和Ｖｉｍｅｎｔｉｎ检测对宫颈腺癌及子宫内膜腺癌有鉴别诊断意义，而ＥＲ、ＣＥＡ对预后和治疗可提供参考指导。
Objective: To investigate the histochemical and immunohistochemical features and clinical significance of endometrial adenocarcinoma. Methods: The histochemical and immunohistochemical methods were used to observe the content of mucin, distribution and expression of immunopositives. Results: Endometrial adenocarcinoma and cervical adenocarcinoma have different mucin contents and distributions: endometrial adenocarcinoma has a low mucin content and is mainly composed of mucin sulfate, whereas cervical adenocarcinoma is rich in content and sticks with salivary acid. Protein-based. The positive expression rate of vimentin in endometrial adenocarcinoma was 73.3%, but negative in cervical adenocarcinoma. The expression of estrogen receptor (ER), carcinoembryonic antigen (CEA) and proliferating cell nuclear antigen (PCNA) has no significant difference in tumor classification, but it has certain significance for prognosis and grading. The clinical endocrine therapy efficacy and prognosis of ER-positive patients are better. However, CEA has a certain relationship for early tumor metastasis. Conclusion: Histochemistry and Vimentin test have differential diagnostic value for cervical adenocarcinoma and endometrial adenocarcinoma. ER and CEA can provide reference for prognosis and treatment.