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目的研究血清脂蛋白(a)对糖尿病肾病的早期诊断价值。方法选择61例健康体检人员作为正常对照组,另选择87例2型糖尿病无白蛋白尿患者(DM1组)、99例2型糖尿病微量白蛋白尿患者(DM2组)和43例2型糖尿病大量白蛋白尿患者(DM3组)作为研究组,均用胶乳浊度法测定血清脂蛋白(a)。结果与正常对照组血清脂蛋白(a)273±26L1mg/L相比较,DM2组血清脂蛋白(a)510±33L1mg/L(P<0.01),DM3组血清脂蛋白(a)901±35L1mg/L,(P<0.01),均有统计学意义。结论血清脂蛋白(a)测定对糖尿病肾病具有早期诊断价值。
Objective To study the value of serum lipoprotein (a) in the early diagnosis of diabetic nephropathy. Methods Sixty-one healthy subjects were selected as the normal control group. Eighty-seven DM1 patients with type 2 diabetes mellitus, DM2 DMEM with type 2 diabetes mellitus (DM2 group), and 43 DM2 patients with type 2 diabetes mellitus Patients with albuminuria (DM3 group) served as the study group, and serum lipoprotein (a) was determined by latex turbidimetry. Results Serum lipoprotein (a) was 510 ± 33L1mg / L in DM2 group (P <0.01), compared with 273 ± 26L1mg / L in normal control group (a) 901 ± 35L1mg / L, (P <0.01), all with statistical significance. Conclusion Serum lipoprotein (a) has early diagnostic value for diabetic nephropathy.