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目的:探讨慢性肾衰竭(CRF)患者治疗前后血清胱抑素C(Cys C)、同型半胱氨酸(Hcy)及甲状旁腺激素(PTH)水平变化及临床意义。方法:筛选2013年12月至2014年12月我院就诊的CRF患者258例作为研究组,并选取同时期健康体检者258例为对照组,研究组患者入院后针对病情给予相应治疗,检测研究组治疗前后血清肌酐(Scr)、尿素氮(BUN)、Cys C、Hcy及PTH水平变化,分析不同分期CRF患者各指标的水平差异,并与对照组进行对比分析,分析Scr、BUN与Cys C、Hcy及PTH的相关性。结果:研究组血清Scr、BUN、PTH、Cys C和Hcy水平均明显高于对照组,异有统计学意义(P<0.05),经过治疗后以上各项指标水平较前明显下降,差异有统计学意义(P<0.05),但仍明显高于对照组,差异有统计学意义(P<0.05);研究组患者Scr、BUN、Cys C、Hcy及PTH水平随着CRF分期发展而上升,其中尿毒症期>肾功能衰竭期>肾功能失代偿期>肾功能代偿期,组间比较差异均有统计学意义(P<0.05);采用Pearson相关性分析,研究组患者的Scr、BUN水平分别与Cys C、Hcy及PTH的水平呈正相关(r=0.731、0.642、0.813,P<0.05;r=0.682、0.752、0.833,P<0.05)。结论:Cys C、Hcy、PTH水平能够反映CRF患者临床治疗效果,反映疾病的严重程度,为CRF患者的诊断和预后提供参考,具有重要的临床意义。
Objective: To investigate the changes of serum cystatin C (Cys C), homocysteine (Hcy) and parathyroid hormone (PTH) in patients with chronic renal failure (CRF) and their clinical significance. Methods: A total of 258 CRF patients admitted to our hospital from December 2013 to December 2014 were enrolled in this study. 258 healthy people were enrolled in the study. The patients in the study group were given appropriate treatment according to their condition after admission. The levels of serum creatinine (Scr), blood urea nitrogen (BUN), Cys C, Hcy and PTH in patients with different stages of CRF were analyzed before and after treatment. The levels of Scr, BUN and Cys C , Hcy and PTH. Results: The serum levels of Scr, BUN, PTH, Cys C and Hcy in the study group were significantly higher than those in the control group (P <0.05). After treatment, the above indexes were significantly decreased, with statistical differences (P <0.05), but still higher than the control group (P <0.05). The levels of Scr, BUN, Cys C, Hcy and PTH in the study group increased with the progress of CRF staging Uremia period> Renal failure> Renal decompensation> Renal decompensation, the differences between the two groups were statistically significant (P <0.05); Pearson correlation analysis, the study group of patients with Scr, BUN The levels were positively correlated with the levels of Cys C, Hcy and PTH (r = 0.731,0.642,0.813, P <0.05; r = 0.682,0.752,0.833, P <0.05). Conclusion: The levels of Cys C, Hcy and PTH can reflect the clinical effect of CRF patients and reflect the severity of the disease, so as to provide reference for the diagnosis and prognosis of patients with CRF. It has important clinical significance.