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目的探讨原发性皮肤CD30+间变大细胞淋巴瘤(C-ALCL)的临床病理特征、免疫表型及预后,提高对C-ALCL的认识和病理诊断水平。方法对6例C-ALCL进行临床病理分析及免疫组化染色。结果 6例中男性3例,女性3例,中位年龄45岁。以皮肤结节为主要临床表现。组织学上具有间变大细胞淋巴瘤的形态特征,瘤细胞体积大,有明显的多形性和异形性,免疫组化6例瘤细胞弥漫表达CD30+,2例ALK+,3例EMA+,T细胞标记可有CD3、CD4、CD45RO或TIA-1的表达,均不表达CK、CD20、S-100、HMB45。结论 C-ALCL少见,掌握其形态学及免疫组化特点对诊断、鉴别诊断及预后具有重要意义。
Objective To investigate the clinicopathological characteristics, immunophenotype and prognosis of primary cutaneous CD30 + large cell lymphoma (C-ALCL) and to improve the level of understanding and pathological diagnosis of C-ALCL. Methods Six cases of C-ALCL were studied with clinicopathological and immunohistochemical staining. Results 6 males in 3 cases, 3 females, the median age of 45 years. The main clinical manifestations of skin nodules. Histologically, with the morphological features of metaplastic large cell lymphoma, the tumor cells were bulky, with obvious pleomorphism and atypia. Immunohistochemically, 6 cases of tumor cells diffusely expressed CD30 +, 2 cases of ALK +, 3 cases of EMA + T cells The marker may have the expression of CD3, CD4, CD45RO or TIA-1, neither express CK, CD20, S-100, HMB45. Conclusion C-ALCL is rare, and its morphological and immunohistochemical characteristics of the diagnosis, differential diagnosis and prognosis of great significance.