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目的 探讨严重急性呼吸综合征 (SARS)患者的激素用法与预后关节肿痛的关系。方法 通过分析对 SARS期间的病历资料和医嘱 ,回顾性调查 30例无基础疾病患者的一般情况和激素用法 (包括激素使用总量、持续时间、最高剂量、最高剂量使用持续时间、减药速度 ) ;患者出院 1个月后 ,统一组织调查 SARS患者预后关节痛的有关情况。统计分析采用多元逐步回归法。结果 SARS患者治疗期间甲基泼尼松龙使用总量为 (42 4 4 .16± 2 2 92 .30 ) m g,使用总时间为 (2 5 .36± 5 .88) d,最高剂量为 (32 1.33± 174 .0 3) m g/ d,最大剂量使用持续时间 (7.73± 4 .0 8) d,减药速度为 (2 1.33± 10 .18) mg/ d。恢复期间出现关节痛 2 6例 ,占 86 .6 7% ;从发病之日到关节痛出现的时间 ,以 1个月以内组发病患者数最多 (为 9例 ) ,占 34.6 2 % ;晚上疼痛明显者仅占 7.6 9% (2例 ) ;轻度疼痛者最多 ,占 5 3.85 %。单因素分析显示 :关节痛程度与激素总量、用药持续时间、用药最大剂量、最大剂量持续时间、停药速度有相关关系 ;关节痛持续时间与激素总量、用药持续时间、用药最大剂量有相关关系 ;年龄与关节痛程度和持续时间都无相关关系。多因素分析显示 :关节痛程度仅与激素使用总量有关 ,关节痛持续时间与激素使用持续时间
Objective To investigate the relationship between hormone usage and prognosis in patients with severe acute respiratory syndrome (SARS). Methods The general situation and hormone usage of 30 patients without underlying diseases (including the total amount of hormone used, the duration, the highest dose, the duration of the highest dose, and the speed of drug reduction) were retrospectively analyzed by analyzing the medical record data and doctor ’s orders during the SARS. One month after the patients were discharged from hospital, the organizations were investigated for the prognosis of patients with SARS. Statistical analysis using multiple stepwise regression. Results The total amount of methylprednisolone used in the treatment of SARS patients was (42 44.16 ± 2292.30) mg, the total time used was (25.36 ± 5.88) d, the highest dose was ( 32 1.33 ± 174 .0 3) mg / d, duration of maximum dose duration (7.73 ± 4.80) d, and rate of drug reduction (2.33 ± 10.18) mg / d. There were 26 cases of arthralgia during recovery, accounting for 86.67%. From the time of onset to the time of appearance of joint pain, the incidence of arthritis in one month was the highest (9 cases), accounting for 34.6% Only 7.69% (2 cases) were obvious, while those with mild pain accounted for 5 3.85%. Univariate analysis showed that the degree of joint pain was related to the total amount of hormones, the duration of medication, the maximum dose, the maximum dose duration and the withdrawal rate. The duration of joint pain, the total amount of hormone, the duration of medication, the maximum dose of medication Correlation; Age and the degree and duration of joint pain have no correlation. Multivariate analysis showed that the degree of joint pain was only related to the total amount of hormone used, the duration of joint pain and duration of hormone use