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目的:评估围生期感染人类免疫缺陷病毒(HIV)患儿丙肝病毒(HCV)感染率。设计:采用横断面研究。机构:美国41个地方进行了多中心研究。受试者:从某大型长期随访研究中随机选择围生期感染HIV的儿童。主要观察指标:HCV抗体和HCV RNA阳性作为丙肝病毒感染的确诊指标。结果:进入研究的530个儿童中525人进行了HCV检验。受检者83%是少数民族,男女平均分布,年龄中位数为10.7岁,75%的受试者CD4.+ 淋巴细胞计数>50个/mm3。525名感染HIV的儿童有8名(1.5%,95%CI 0.7%-3.0%)复合感染丙肝病毒, 而国家健康营养普查时对2 700名6-11岁儿童进行了HCV血清学检查,感染率为0.2%(95%CI 0.04% -0.6%)。本研究表明感染HIV后复合感染HCV的儿
Objective: To assess the prevalence of hepatitis C virus (HCV) infection in children with perinatal infection with human immunodeficiency virus (HIV). Design: Use cross-sectional study. Institutions: Multi-center studies were conducted in 41 places in the United States. Subjects: Children randomly selected for perinatal HIV infection from a large, long-term follow-up study. MAIN OUTCOME MEASURES: The positive of HCV antibody and HCV RNA as the diagnosis of hepatitis C virus infection. RESULTS: Of the 530 children enrolled in the study, 525 were HCV tested. 83% of subjects were ethnic minorities with an average age distribution of 10.7 years. 75% of subjects had CD4 + lymphocyte counts> 50 / mm3.525 children infected with HIV (1.5 %, 95% CI 0.7% -3.0%), and 2,700 children 6-11 years of age were serologically tested for HCV at the National Health Nutrition Census, with an infection rate of 0.2% (95% CI 0.04% 0.6%). This study shows that children infected with HIV and subsequently co-infected with HCV