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目的 :探讨P物质在高原地区慢性肺心病发病中的作用及其与病情及肺功能的关系。方法 :用放射免疫分析法检测高原地区 (海拔 2 2 6 0～ 330 0m) 30例健康受试者 ,30例慢性肺心病患者急性加重期和缓解期痰中P物质浓度 ,同时检测肺功能 ,分析痰中P物质含量与一秒钟用力呼气容积 (FEV1)占预计值百分比 (FEV1% )、FEV1/用力肺活量 (FVC)比值的相关关系。结果 :肺心病组急性加重期痰中P物质浓度 ( 73.8± 12 .5 )pmol·L-1显著高于缓解期 ( 5 7.3± 10 .1)pmol·L-1(P <0 .0 1) ,并显著高于健康对照组 ( 8.2± 2 .2 )pmol·L-1(P <0 .0 1)。肺心病组急性加重期和缓解期痰中P物质浓度与FEV1%、FEV1/FVC比值均呈显著负相关 (r值分别为 - 0 .6 5 4、- 0 .5 98、- 0 .6 6 7、- 0 .5 76 ,P均 <0 .0 1)。结论 :神经源性炎症可能参与了高原慢性肺心病气道炎症过程及随后的气道狭窄
Objective: To investigate the role of substance P in the pathogenesis of chronic cor pulmonale and its relationship with disease and pulmonary function in the plateau area. Methods: Radioimmunoassay was used to detect the levels of substance P in sputum from 30 healthy subjects and 30 chronic pulmonary heart disease patients in the plateau (elevation 2 220 ~ 330 0 m). The lung function, The relationship between substance P content in sputum and forced expiratory volume one second (FEV1) as a percentage of expected value (FEV1%) and FEV1 / FVC was analyzed. Results: The concentration of substance P (73.8 ± 12.5 pmol·L-1) in acute stage of acute exacerbation of pulmonary heart disease group was significantly higher than that of remission stage (7.3 ± 10.1 pmol·L-1) (P <0.01) ), Which was significantly higher than that of the healthy control group (8.2 ± 2.2) pmol·L-1 (P <0.01). Pulmonary heart disease group acute exacerbation and remission sputum P substance concentration and FEV1%, FEV1 / FVC ratio showed a significant negative correlation (r values ?? -0.646, -0.598, -0.66 7, -0.57, all P <0.01). Conclusion: Neurogenic inflammation may be involved in airway inflammation and subsequent airway stenosis