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目的观察小剂量131I多次给药在甲状腺功能亢进(甲亢)治疗中的应用效果。方法选择在2012年6月—2013年5月间,在齐齐哈尔医学院第一附属医院核医学科诊治的59例甲亢患者作为观察组,给予50~80μCi/g甲状腺组织的131I小剂量多次重复服用,选择2011年6月—2012年5月间诊治的甲亢患者60例作为对照组,给予剂量为100~120μCi/g甲状腺组织的131I一次性口服,比较两组患者治疗后的甲功指标,白细胞水平,同时记录治疗有效率和甲状脉功能减退(甲减)发生率,计数资料采用χ2检验,计量资料采用t检验,P<0.05为差异有统计学意义。结果观察组患者的治疗有效率为100%,对照组治疗有效率为100%,两组疗效比较差异无统计学意义(P>0.05);两组在甲状腺功能减低发生率(5%、21.7%)比较差异有统计学意义(P<0.05)。两组患者治疗后在FT3、FT4、TSH、WBC比较,差异均无统计学意义(P>0.05)。结论采用I131小剂量多次给药,能够取得和常规治疗方法相同的治疗效果,并且能够有效降低患者甲减的发生率,值得临床推广应用。
Objective To observe the effect of multiple doses of 131I in the treatment of hyperthyroidism (hyperthyroidism). Methods From June 2012 to May 2013, 59 patients with hyperthyroidism diagnosed and treated in the Department of Nuclear Medicine, the First Affiliated Hospital of Qiqihar Medical College were selected as the observation group and received 131I low dose multiple repetition of 50-80μCi / g thyroid tissue Taking 60 patients with hyperthyroidism who were diagnosed and treated between June 2011 and May 2012 as the control group, giving a dose of 100 ~ 120μCi / g thyroid 131I once a one-time oral comparison of two groups of patients after treatment of thyroid function indicators, Leukocyte levels, meanwhile, the treatment efficiency and the incidence of thyroid hypothyroidism (hypothyroidism) were recorded. The count data were analyzed byχ2 test and the t test was used for measurement data. The difference was statistically significant at P <0.05. Results The effective rate of treatment was 100% in the observation group and 100% in the control group, with no significant difference between the two groups (P> 0.05). The incidences of hypothyroidism (5%, 21.7% ) Difference was statistically significant (P <0.05). There was no significant difference in FT3, FT4, TSH and WBC between the two groups after treatment (P> 0.05). Conclusions The I131 low-dose multiple administration can achieve the same therapeutic effect as conventional treatment, and can effectively reduce the incidence of hypothyroidism, which is worthy of clinical application.