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目的探讨改变阿托品与氯解磷定的给药方式对抢救急性有机磷农药中毒(AOPP)疗效的影响。方法符合急性重度有机磷农药中毒患者46例,随机分为治疗组24例,对照组22例,治疗组先给予负荷量的阿托品与氯解磷定静脉注射,之后通过持续泵入的方式继续给药,对照组先给予负荷量的阿托品与解磷定静脉注射,之后采取反复间歇静脉注射的方式继续给药,观察两组间阿托品化时间、达到阿托品化所需阿托品的量、阿托品总量、反跳、中间综合征和阿托品中毒的发生率以及住院时间和治愈率的差异。结果治疗组与对照组阿托品化时间、达到阿托品化所需阿托品量、中间综合征发生率、住院时间、治愈率无显著性差异(P>0.05),而两组间的阿托品总量、反跳率、阿托品中毒率有显著性差异(P<0.05)。结论负荷量后持续泵入阿托品与氯解磷定抢救急性重度有机磷农药中毒,疗效可靠、安全,并可减少护理工作量,节约人力。
Objective To explore the effect of atropine and chlorophenanthrate on the efficacy of acute organophosphorus pesticide poisoning (AOPP). Methods Forty-six patients with acute severe organophosphorus pesticide poisoning were randomly divided into treatment group (n = 24) and control group (n = 22). The patients in treatment group were given intravenous injection of atropine and chlorophenanthroline intravenously, then continued to pump Medicine and control group were given first dose of atropine and phosphate solution given intravenously, then repeated intermittent intravenous injection to continue administration, observation of atropine in the time between the two groups to achieve the amount of atropine required atropine, the total amount of atropine, Rebound, intermediate syndrome and the incidence of atropine poisoning and hospital stay and cure rate differences. Results The time of atropine treatment, the amount of atropine required for atropisation, the incidence of intermediate syndrome, the length of hospital stay, and the cure rate were not significantly different between the treatment group and the control group (P> 0.05). The total amount of atropine between the two groups rebounded Rate, atropine poisoning rate was significantly different (P <0.05). Conclusions After the load is continuously pumped into atropine and chlorophenanthroline to rescue acute severe organophosphorus pesticide poisoning, the curative effect is reliable and safe, and it can reduce the nursing workload and save manpower.