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一、气道过敏性的测定法和临床意义人的诱发试验是在四十年代开始的。日本从1943年开始,吸入乙酰胆硷,健康者平均用9,540μg/ml,喘息患者平均为113μg/ml。吸入组织胺,健康者10,000μg以上,喘息患者(145例)有93%降低到1,000μg以下。近来注意到难治性喘息患者的发病和气道过敏性之间的关系,作者曾报告吸入组织胺在20μg以下的37例中有54%为难治性喘息。综合临床症状,胸部X线检查,支气管造影,肺功能测定等诊断为慢性阻塞性肺部疾病的201例中,中等度以上(吸入组织胺阈值在200μg以下)的气道过敏性患者的比率:单纯喘息组(64例)63%,喘息合并慢性支气管炎组(69例)
First, the airway allergy determination and clinical significance of human induced test was started in the forties. Japan began acetylcholine inhalation in 1943, with an average of 9,540 μg / ml in healthy subjects and an average of 113 μg / ml in asthmatic patients. Histamine inhalation, healthy over 10,000μg, asthmatic patients (145 cases) 93% reduced to less than 1,000μg. Recently, noting the relationship between the onset of refractory wheeze and airway anaphylaxis, the authors have reported that 54% of the 37 patients who inhaled histamine below 20 μg are refractory wheeze. Among 201 cases diagnosed as chronic obstructive pulmonary disease with moderate clinical symptoms, thorax X-ray examination, bronchial angiography and pulmonary function test, the rate of airway allergic patients with moderate or higher (inhaled histamine threshold below 200 μg) Sixty-three percent in the asthmatic group (n = 64), the group with asthma combined with chronic bronchitis (n = 69)