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为了探讨卵子赠送妊娠后胎盘类固醇激素产生的时间；外源性激素替代治疗的合理剂量和疗程；药物减量和停药的指征。采用低剂量类固醇激素替代与卵子赠送技术使５例卵巢早衰患者、２例绝经前期患者获得单胎妊娠，在孕４～１２周应用放射免疫法连续测定血清雌二醇（Ｅ２）、雌三醇（Ｅ３）及孕酮（Ｐ）水平，并与５例正常单胎妊娠同期水平比较。结果：７例卵子赠送单胎妊娠均于孕１２周安全停药，均足月分娩。Ｅ２和Ｐ水平分别于孕５和６周开始上升，孕６和７周明显高于孕４周基础值（Ｐ分别＜０．００１和＜０．００２）。孕７～１２周血清Ｅ２水平与正常单胎妊娠组同期水平相似。血清Ｅ３水平从孕６～７周开始升高，孕１０～１１周稳定于２０～３０μｇ／Ｌ范围，与正常单胎妊娠组无区别。结论：胎盘组织从孕５～７周开始分泌Ｅ２和Ｐ进入母体外周血，提示胎盘功能出现，可考虑药物逐渐减量。Ｅ３从孕１０周起稳定在中期妊娠水平，提示黄体与胎盘功能交替完成，此时应停用外源性激素。
In order to explore the time of egg presentation of placental steroid hormone after pregnancy, rational dose and course of exogenous hormone replacement therapy, drug reduction and indication of withdrawal. Low-dose steroid hormone replacement and egg donation technology in 5 cases of premature ovarian failure, 2 cases of pre-menopausal patients with single-fetus pregnancy, 4 weeks to 12 weeks of pregnancy by radioimmunoassay continuous determination of serum estradiol (E2), estriol (E3) and progesterone (P), and compared with the same period of five normal singleton pregnancies. Results: All the 7 singleton pregnancies were given a single pregnancy at 12 weeks of gestation and were given full term labor. The levels of E2 and P began to rise at 5 and 6 weeks of pregnancy, respectively. The levels of E2 and P at 6 and 7 weeks of pregnancy were significantly higher than those at 4 weeks of pregnancy (P <0.001 and <0.002, respectively). Serum E2 levels at 7-12 weeks of gestation were similar to those at the same period of normal singleton pregnancies. Serum E3 levels began to increase from 6 to 7 weeks of gestation, and stabilized in the range of 20 to 30 μg / L in 10 to 11 weeks of gestation, showing no difference from normal singleton pregnancies. Conclusion: The placental tissue begins to secrete E2 and P into the maternal peripheral blood from 5 to 7 weeks’ gestation, which indicates that the placental function appears and the drug may be gradually reduced. E3 from 10 weeks pregnant stable in the level of second trimester, suggesting that the function of the corpus luteum and the placenta alternately completed, this time should be disabled exogenous hormones.