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目的观察脑血管病患者血清肿瘤坏死因子（TNF）、白细胞介素-08（IL－8）水平的动态变化。方法采用ELISA法分别测定95例脑血管病患者起病＜1周及≥4周的血清TNF、IL－8水平。结果脑血管病患者血清NNF、IL－8水平较正常对照组增高，起病＜1周者血清TNF、IL－8水平较≥起病4周者升高显著；起病≥4周者脑梗死组血清TNF、IL-8和脑出血组TNF有明显下降，但仍高于正常对照组，脑出血组IL－8与正常对照组无明显差异。结论血清IL－8、TNF水平的动态监测对脑血管疾病（CVD）发生、发展及其预后判断具有一定预测价值。
Objective To observe the dynamic changes of serum tumor necrosis factor (TNF) and interleukin-08 (IL-8) in patients with cerebrovascular disease. Methods The levels of serum TNF and IL-8 in 95 patients with cerebrovascular disease onset <1 week and> 4 weeks were determined by ELISA. Results Serum levels of NNF and IL-8 in patients with cerebrovascular disease were significantly higher than those in normal controls. Serum levels of TNF and IL-8 in those with onset less than 1 week were significantly higher than those of patients with ≥ 4 weeks of onset. Cerebral infarction Serum TNF, IL-8 and TNF in cerebral hemorrhage group decreased significantly, but still higher than the normal control group, cerebral hemorrhage group IL-8 and the normal control group no significant difference. Conclusion The dynamic monitoring of serum IL-8 and TNF levels has some predictive value for the occurrence, development and prognosis of cerebrovascular disease (CVD).