论文部分内容阅读
目的观察不同剂量吸入糖皮质激素对稳定期慢性阻塞性肺病的疗效。方法将65例中-重度稳定期慢性阻塞性肺病患者随机分为两组。对照组33例,应用吸入沙美特罗/氟替卡松(50μg/250μg),每次1吸,2次/d。治疗组32例,吸入沙美特罗/氟替卡松(50μg/500μg),每次1吸,2次/d。结果治疗组与对照组肺功能指标均较治疗前有改善,治疗组较对照组肺功能指标改善更加明显(P<0.05);治疗组与对照组生活质量评分较治疗前下降,治疗组较对照组生活质量评分下降更加明显(P<0.05),生活质量明显提高。结论治疗组高剂量吸入糖皮质激素对稳定期慢性阻塞性肺病疗效更好,副作用未见明显增加。
Objective To observe the effect of different doses of inhaled glucocorticoid on stable chronic obstructive pulmonary disease. Methods Sixty-five patients with moderate-severe stable chronic obstructive pulmonary disease were randomly divided into two groups. Control group, 33 cases, the application of salmeterol / fluticasone (50μg / 250μg), each suction 1, 2 times / d. The treatment group of 32 patients, inhaled salmeterol / fluticasone (50μg / 500μg), each suction, 2 times / d. Results The lung function indexes of the treatment group and the control group were better than those before treatment, and the improvement of lung function index of the treatment group was more obvious than that of the control group (P <0.05). The quality of life scores of the treatment group and the control group decreased compared with that before treatment, The quality of life score decreased more significantly (P <0.05), and the quality of life improved significantly. Conclusion High-dose inhaled glucocorticoids in the treatment group have a better effect on stable chronic obstructive pulmonary disease and no significant increase in side effects.