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目前关于肠源性感染较为流行的解释是应激状态使肠黏膜屏障受到破坏,肠免疫功能受损,肠道菌群失调,条件致病菌异常增殖,活菌及其产生的毒素通过肠屏障侵入肠道以外的部位,导致促炎因子的释放,引起局部炎症或全身反应综合征,甚至多器官功能障碍。本综述旨在探讨细菌的生物学行为变化与肠源性感染发生的关系。
At present, the more popular explanation for gut infection is that the stress state damages the intestinal mucosal barrier, impaired intestinal immune function, dysbacteriosis of the gut flora, abnormal proliferation of opportunistic pathogens, passage of live bacteria and toxins produced by them through the gut barrier Invasion of other parts of the intestine, leading to the release of proinflammatory cytokines, causing local inflammation or systemic response syndrome, and even multiple organ dysfunction. The purpose of this review is to explore the relationship between bacterial biological behavior changes and the occurrence of gut-derived infections.