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目的:研究肠外营养对胃癌患者化疗期间免疫功能的影响。方法:选取2009年6月~2011年6月我院的100例胃癌患者为研究对象,随机分为2组,肠外营养组50例给予全肠外营养治疗,肠内营养组50例化疗期间给予肠内营养,化疗开始后第1天开始行肠外或肠内营养支持,持续8天。检测并记录化疗前和化疗后第8天患者的细胞免疫指标CD3、CD4、CD8和NKC活性及体液免疫指标IgA、IgG、IgM。结果:肠外营养组化疗后CD3、CD4、CD8值及NKC活性明显下降,IgA、IgG、IgM值明显升高;肠内营养组化疗后CD3、CD4、CD8水平和NKC活性与化疗前相比无显著性变化,IgA、IgG、IgM水平也明显升高。结论:肠外营养对胃癌病人化疗后细胞免疫功能无明显改善作用,肠内营养有明显的细胞免疫增强作用,可有效地纠正胃癌病人化疗后细胞免疫抑制状态。
Objective: To study the effect of parenteral nutrition on immune function of gastric cancer patients during chemotherapy. Methods: From June 2009 to June 2011, 100 patients with gastric cancer in our hospital were selected and randomly divided into two groups. 50 patients in the parenteral nutrition group received total parenteral nutrition and 50 patients in the enteral nutrition group received chemotherapy Enteral nutrition was given, and parenteral or enteral nutrition was started on the first day after chemotherapy started for 8 days. The cellular immune indexes CD3, CD4, CD8 and NKC activity and humoral immune indexes IgA, IgG and IgM were measured before and after chemotherapy. Results: The levels of CD3, CD4, CD8 and NKC activity in the parenteral nutrition group decreased significantly and IgA, IgG and IgM values increased significantly. The levels of CD3, CD4, CD8 and NKC in the enteral nutrition group were significantly higher than those before chemotherapy No significant change, IgA, IgG, IgM levels were significantly higher. Conclusion: Parenteral nutrition has no significant effect on cellular immune function after chemotherapy in patients with gastric cancer, and enteral nutrition has significant cellular immunity enhancing effect, which can effectively correct the immunosuppressive status of patients after gastric cancer chemotherapy.