论文部分内容阅读
作者用乙酰胆碱输注法测定冠脉内皮功能,用中性粒细胞清除法及血小板激活因子拮抗剂(CV-3988)评价中性粒细胞在再灌注损伤中的作用。小羊麻醉开胸建立体外循环后,从心尖向左室插入气囊导管测定左室功能,记录左室压力和dp/dt。收缩功能的恢复用最大峰压DPmax(收缩峰压减去舒张末压)、LVdp/dt最大正值和负值、气囊容积恒定(V_(10))时的峰压和dp/dt评价,舒张功能的恢复用等容舒张末压(V_(10))评价。磁流量计持续测定冠脉血流量。输注乙酰胆碱后冠脉阻力(CVR)降低最大幅度除以基础CVR为冠脉阻力反应(CVRR),来评价冠脉内皮功能。其
The authors used acetylcholine infusion to determine endothelial function and used neutrophil clearance and platelet activating factor antagonist (CV-3988) to evaluate the role of neutrophils in reperfusion injury. Lamb anesthesia thoracotomy to establish cardiopulmonary bypass, from the apex to the left ventricle inserted balloon catheter determination of left ventricular function, recording left ventricular pressure and dp / dt. The recovery of systolic function was assessed by peak pressure and dp / dt at maximum peak pressure DPmax (peak systolic pressure minus end diastolic pressure), maximum positive and negative values of LVdp / dt, balloon volume constant (V_ (10)), Functional recovery was assessed by isovolumic end-diastolic pressure (V_ (10)). Magnetic flowmeter continuous measurement of coronary blood flow. Coronary endothelial function was assessed by the most significant reduction in coronary resistance (CVR) after infusion of acetylcholine divided by basal CVR for coronary resistance (CVRR). its