KAI1/CD82基因与胃癌关系的研究进展

• 作 者: 徐广敏 李春鸣
• 机 构: 遵义医学院附属医院病理科,
• 出 处: 遵义医学院学报
• 发表日期: 2013年02期
• 关键词: KAI1/CD82 基因突变 血管生成 正常胃组织 剪接体 程中 转移抑制基因 胃粘膜上皮 转移状态 低表达

胃癌是目前死亡率较高的恶性肿瘤之一,而胃癌的局部浸润和远处转移是其病程中最危险的因素,也是导致治疗失败的主要原因。肿瘤的转移是一个高度复杂的过程,它涉及肿瘤细胞基因表达突变引起肿瘤细胞的变异、增殖、血管生成等一系列变化。因此,了解胃癌发生转移的机制及其影响

Gastric cancer is currently one of the malignant tumors with high mortality rate. However, the local invasion and distant metastasis of gastric cancer are the most dangerous factors in the course of their disease, which is also the main reason for the failure of treatment. Tumor metastasis is a highly complex process involving a series of changes in the tumor cells such as mutation, proliferation and angiogenesis caused by the mutation of gene expression in tumor cells. Therefore, to understand the mechanism of gastric cancer metastasis and its impact