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目的拟使用红色色度坐标探讨家兔脑干出血条件下的十二指肠及空肠粘膜绒毛的微循环动态变化 ,以期建立起消化道微循环的检测机制 ,为预防和治疗脑干出血并发消化道出血这一难症提供参考指标。方法用日本大耳白家兔 (雄性 ) ,体重1.6kg左右 ,25只进行活体实验 ,使用25 %Urethane静脉麻醉 ,施行颅骨开窗手术做成急性脑干出血动物模型。使用微循环显微镜血管摄像装置及微循环电视录像系统连续测定脑干出血条件下的十二指肠及空肠粘膜绒毛充血程度 ,使用计算机Photo shop软件连续解析同一绒毛同一空间坐标点上的红色色度坐标的经时变化 ,做成小肠绒毛同一位点上的红色坐标的经时移行曲线。结果1.显示脑干出血负荷后空肠粘膜绒毛的一过性充血程度增大及随后的恢复经过。2.显示脑干出血负荷后的十二指肠粘膜的红色色度减低 (苍白 )及与之同步的微小形态改变。结论在本实验条件下 ,通过粘膜色度分析可在一定程度上反映出粘膜血流这一最重要的溃疡防御因子在急性脑干出血条件下的急剧改变 ,可成为随之产生的应激性溃疡的病理生理基础 ,为今分析应激性溃疡的粘膜血流经时变化提供了重要的参考依据
Objective To explore the dynamic changes of microcirculation of duodenum and jejunal mucosa villus under the condition of brainstem hemorrhage in rabbits in order to establish the detection mechanism of microcirculation of digestive tract in order to prevent and treat the simultaneous digestion of hemorrhage Road bleeding provides a reference indicator of this difficult disease. Methods Japanese white rabbits (male), weighing about 1.6kg, 25 were in vivo experiments, using 25% Urethane intravenous anesthesia, the implementation of cranial fenestration in acute brain stem hemorrhage animal model. Microcirculation microscope and microcirculation video recording system were used to measure the degree of congestion of duodenum and jejunum mucosa under the condition of hemorrhage of brainstem. The computerized Photo shop software was used to continuously analyze the red chroma of the same villus coordinate point Time-dependent changes in the coordinates of the same site made of red villi of red coordinates of the time-shift curve. Results 1. Shows a transient hyperemia of jejunal mucosal villi after brainstem hemorrhage load and subsequent recovery. 2. Reduce duodenal mucosa redness (pale) and synchronize with slight morphological change after displaying brainstem hemorrhage load. Conclusions Under this experimental condition, mucosal chromaticity analysis can to some extent reflect the rapid change of mucosal blood flow, the most important ulcerative defensive factor, under the condition of acute brainstem hemorrhage and can be the consequent stress The pathophysiology of ulcer basis for the analysis of stress ulcer mucosal blood flow over time provides an important reference