Identification of novel Lynch syndrome mutations in Chinese patients with endometriod endometrial ca

• 作 者: Caixia Ren Yan Liu Yuxiang Wan
• 机 构: KeyLaboratoryofCarcinogenesisandTranslationalResearch,DepartmentofHumanAnatomy,DepartmentofPathology
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2020年2期
• 关键词: DNA mismatch repair endometrial endometrioid cancer germline mutation Lynch synd
• 基金项目: grants from the National Key Research and Development Program of China to CL(grant No.2018 YFC1004002),National Natural Science Foundation of China(grant Nos.81730071,81472734 and 81321003 to HZ and 8

Objective:Lynch syndrome(LS)predisposes patients to early onset endometrioid endometrial cancer(EEC).However,little is known about LS-related EEC in the Chinese population.The aim of this study was to investigate the prevalence of LS and to identify the s