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慢性粒细胞型白血病急变病程中可观察到两种治疗效应类型,其中一型经细胞组织化学检查证明是淋巴细胞性的,但Ph~1染色体持续存在,提示这是从粒细胞系演变而来的。然而,最近实验资料使一些学者同意淋巴细胞来源的看法。过去3年中,作者等观察20例慢粒急变,用分带技术检查血液和骨髓的染色体,17例Ph~1染色体持续存在。20例中有4例经细胞组织化学检查表现有淋巴细胞特性,用Canellos方案(长春新碱+强的松)治疗,其中3例完全缓解6个月。16例非淋巴细胞型,用柔红霉素、阿糖胞甙和6-硫乌嘌呤治疗,只有2例完全缓解,4例部分缓解,10例无效。对治疗的不同效应以及淋巴细胞型治疗的特别敏感性使作者等
Two types of treatment effects were observed in the course of acute myeloid leukemia, one of which was proved to be lymphocytic by cytochemical examination, but persistence of the Ph ~ 1 chromosome suggests that this has evolved from the granulocytic lineage of. However, recent experimental data have led some scholars to agree with the idea of lymphocyte origin. In the past three years, the authors observed 20 cases of chronic myoepithelial abruption. The chromosomes of blood and bone marrow were examined by zonation, and 17 Ph ~ 1 chromosomes persisted. Four of the 20 patients had lymphocytic manifestations by cytochemical examination and were treated with the Canellos regimen (vincristine + prednisone), 3 of whom were completely relieved for 6 months. Of 16 non-lymphoid cells treated with daunorubicin, cytarabine and 6-sulpiride, only 2 were completely relieved, 4 were partially relieved, and 10 were ineffective. The different effects on treatment and the particular sensitivity of lymphocyte-type therapy to the authors