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目的 观察米索前列醇 5 0 μg阴道给药用于晚期妊娠引产的临床效果及副作用。 方法 选择有引产指征 ,单胎头位 ,无应激试验 (NST)为反应型 ,无胎膜早破 ,无应用前列腺素禁忌症的晚期妊娠初产妇 36例 ,米索前列醇 5 0 μg放置阴道后穹窿 ,4h1次 ,直至有规律宫缩 ,最大剂量 60 0 μg ,有规律宫缩或破膜后停用。 结果 36例产妇 30例成功 ,成功率为 83 3%。规律宫缩至分娩时间为 12 2 5± 2 0 5h。自然分娩 2 1例 ,阴道助产 3例 ,剖宫产 6例。 2例产妇出现腹泻 ,1例产妇轻度恶心 ,均为一过性。 7例宫缩过强 ,发生率为 19 4%。结论 米索前列醇 5 0 μg阴道给药用于晚期妊娠引产有效、安全 ,副作用少 ,但应严密观察产程 ,发现宫缩异常应及时处理。
Objective To observe the clinical effect and side effects of vaginal administration of misoprostol (50 μg) during late pregnancy. Methods Induction of labor induction, single head position, no stress test (NST) for the reaction type, no premature rupture of membranes, no prostaglandin contraindications in 36 cases of early pregnancy in primipara, misoprostol 50 μg After placing the vaginal fornix, 4h1 times, until the regular contractions, the maximum dose of 60 0 μg, regular contractions or deactivation after rupture of membranes. Results 36 maternal 30 cases were successful, the success rate was 83 3%. Regular contractions to delivery time of 12 2 5 ± 2 0 5h. 21 cases of natural childbirth, 3 cases of vaginal delivery, cesarean section in 6 cases. Two cases of maternal diarrhea, one maternal mild nausea, were transient. 7 cases of contractions too strong, the incidence was 19 4%. Conclusions Misoprostol (50 μg) vaginally is effective and safe for induction of labor during late pregnancy. However, fewer side effects should be observed. Obstetric procedures should be closely observed and abnormal contractions should be treated in time.