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近来报导痤疮和/或多毛妇女中约有1/3血浆雄激素水平增高,以血浆游离睾酮(FT)及硫酸脱氢表雄酮(DHEAS)升高为特征。本文对31例以皮肤症状为主诉的高雄激素血症妇女行低剂量促肾上腺皮质激素(ACTH)刺激试验,以评价肾上腺雄激素在发病中的作用。试验组年青15～34岁,经皮肤科诊断单纯痤疮12例,单纯多毛2例,痤疮合并多毛17例。评分:痤疮皆>1分,多毛≥7分。肥胖仅1例。全组血浆FT和/或DHEAS水平均增高。试验期间6例在黄体期,25例在非黄体期。对照组为15例19～40岁、月经正常、多毛<7分痤疮≤1分的妇女。受试者于试验前晚服地塞米松1.5mg,试验日上午8～10时给予低剂量(10μg/m~2)合成ACTH滴注,分别于滴注后0、30、60分时取血测血浆17-α羟孕烯
It has recently been reported that about 1/3 of the plasma androgen levels of acne and / or hirsutism women are elevated, characterized by elevated free plasma testosterone (FT) and elevated DHEAS. In this paper, 31 cases of hyperandrogenism women with dermatological symptoms as the chief complaint were given low-dose ACTH stimulation test to evaluate the role of adrenal androgen in the pathogenesis. The experimental group of young 15 to 34 years old, Dermatology diagnosis of simple acne in 12 cases, simple hirsutism in 2 cases, 17 cases of acne combined with hirsutism. Rating: Acne are all> 1 point, hirsutism ≥ 7 points. Only 1 case of obesity. The whole group of plasma FT and / or DHEAS levels were increased. During the trial 6 cases in the luteal phase, 25 cases in the non-luteal phase. Control group of 15 patients 19 to 40 years of age, normal menstruation, hirsutism <7 acne ≤ 1 point of women. Subjects were given dexamethasone 1.5 mg on the night before the test and ACTH instillation at a low dose (10 μg / m ~ 2) at 8-10 am on the test day. Blood samples were taken at 0, 30 and 60 minutes after instillation, respectively Plasma 17-alpha hydroxyestrenol