,Depside salts from Salvia miltiorrhiza improve myocardial microperfusion in rats using laser Dopple

• 作 者: Xiao-fen LI Yi-ping WANG
• 机 构: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for
• 出 处: 中国药理学报（英文版）
• 发表日期: 2007年6期
• 关键词: lithospermate B myocardial microperfu-sion laser Doppler flowmetry cardiac outpu

Aim: To investigate the effects of depside salts from Salvia miltiorrhiza on myo-cardial microperfusion and systemic hemodynamics in open-chest anaesthetized Sprague-Dawley rats.Methods: Myocardial micropeffusion was measured by laser Doppler flowmetry with a needle probe; cardiac output (CO) was determined using ultrasonic Doppler flowmetry. Other hemodynamic parameters, including femoral artery blood pressure, cardiac inotropy, and systemic vascular resistance (SVR) were simultaneously recorded by the PowerLab system.Results: Intrave-nous administration of S miltiorrhiza depside salts resulted in a significant imme-diate increase in CO and cardiac inotropy, but a fall in SVR. S miltiorrhiza depside salts (30 mg/kg and 60 mg/kg) promoted cardiac index (CI) by 12.2%±6.3% (P<0.01vs baseline) and 20.1%±3.5% (P<0.01), respectively. Myocardial microperfusion maximally increased by 6.3%±2.9% (P<0.01) and 9.6%±4.0% (P<0.01) for 30 mg/kg and 60 mg/kg S miltiorrhiza depside salts, respectively.Conclusion: These results indicated that S miltiorrhiza depside salts improved myocardial micro-perfusion, as well as CO.