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目的探讨孕妇乙型肝炎病毒携带状态与母婴传播的关系.方法140例HBsAg阳性孕妇根据乙肝携带状态分为大三阳组及小三阳组,荧光定量PCR法检测两组孕妇血清中HBV-DNA含量,酶联免疫法检测婴儿乙肝状态.结果乙肝大三阳孕妇体内HBV-DNA含量明显高于乙肝小三阳孕妇;新生儿乙肝感染率大三阳组孕妇(19.14﹪)明显高于小三阳组孕妇(1.43﹪),差异有统计学意义;乙肝大三阳孕妇体内HBV-DNA含量>105copy/mL时新生儿感染率显著高于HBV-DNA<105copy/mL组,差异有统计学意义.结论孕妇乙肝携带状态与母婴传播有关,孕妇血HBV-DNA含量越高,新生儿感染率越高.对这类孕妇应加强阻断HBV病毒宫内传播,减少新生儿乙肝感染.“,”objective This study was performed to explore the relationship between the HBV infection status in pregnant women and maternal-infant transmission.Methods 140HBV markers were divided into two groups,the number one group with HBsAg(+),HBeAg(+),HBcAb(+) and the number two group with HBsAg(+),HBeAb(+),HBcAb(+).Quantitative polymerse chain reaction was used to detect the two groups HBV-DNA,infants’s HBV were measured by enzyme linked immunosorbent assay(ELISA).Results HBV-DNA in group number one was significantly higher than the group number two.The positive rate of HBV infected newborns in the group whose mothers have a quantity of HBV-DNA beyond 105copy/mL was significantly higher than the group whose mothers have a less quantity of HBV-DNA.Conclusion the prevalence of HBV infection of the infants is associated with the HBV infection status of the mothers.The more HBV-DNA their mother has,the higher tate the child would infect HBV.It is important to strengthen the blocking of the HBV intrauterine infection of HBV-positive pregnant women,in order to reduce the occurrence of HBV infection in newborns.