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目的观察银杏叶提取物注射液治疗急性脑梗死的临床疗效。方法选取孝义市人民医院神经内科2014年5月—2015年5月收治的急性脑梗死患者760例,按照随机数字表法分为对照组和观察组,各380例。对照组给予常规治疗,观察组在对照组基础上采用银杏叶提取物注射液治疗,7d为1个疗程,2个疗程后观察比较两组患者的血液流变学、炎性因子水平、神经功能缺损量表(NIHSS)评分及不良反应发生情况。结果治疗前两组患者血细胞比容(HCT)、全血黏度(高切)、全血黏度(低切)比较,差异无统计学意义(P>0.05);治疗后观察组HCT、全血黏度(高切)、全血黏度(低切)均低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及白介素6(IL-6)水平比较,差异无统计学意义(P>0.05);治疗后观察组hs-CRP、Hcy及IL-6水平均低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后观察组NIHSS评分低于对照组,差异有统计学意义(P<0.01)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗基础上采用银杏叶提取物注射液治疗急性脑梗死能有效改善患者血液流变学、炎性因子水平及神经功能,提高临床疗效,值得在临床上推广使用。
Objective To observe the clinical efficacy of Ginkgo biloba extract injection in the treatment of acute cerebral infarction. Methods A total of 760 patients with acute cerebral infarction who were admitted to Department of Neurology, Xiaoyi People’s Hospital from May 2014 to May 2015 were divided into control group and observation group according to random number table. The control group was given routine treatment. The observation group was treated with Ginkgo biloba extract injection on the basis of the control group, 7 days for one course of treatment. After 2 courses of treatment, the blood rheology, levels of inflammatory cytokines, neurological function NIHSS score and incidence of adverse reactions. Results There was no significant difference in HCT, whole blood viscosity and whole blood viscosity before and after treatment (P> 0.05). After treatment, HCT, whole blood viscosity (High cut), whole blood viscosity (low cut) were lower than the control group, the difference was statistically significant (P <0.05). There were no significant differences in the levels of hs-CRP, Hcy and IL-6 between the two groups before treatment (P> 0.05). After treatment, the observation group hs-CRP, Hcy and IL-6 levels were lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in NIHSS score between the two groups before treatment (P> 0.05). NIHSS score in observation group was lower than that in control group after treatment (P <0.01). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion The treatment of acute cerebral infarction with Ginkgo biloba extract injection on the basis of conventional treatment can effectively improve the hemorheology, inflammatory cytokines and neurological function, and improve the clinical curative effect. It is worth to be used clinically.