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体内、外构建组织工程化组织的主要障碍都在于缺少足够的血液供应,也就是血管化问题。组织工程血管化的策略目前主要分为两类。第一类是基于内皮细胞等去构建新的血管,在这个过程中生长因子也有促进新生血管的作用。第二类是基于支架技术,包括天然生物衍生的支架和人工合成支架。本文就组织工程血管化策略的研究进展进行综述。
The main obstacle to building tissue engineered tissues both in vitro and externally lies in the lack of adequate blood supply, which is the problem of vascularization. Tissue engineering vascularization strategy is currently divided into two categories. The first category is based on endothelial cells to build new blood vessels, in the process of growth factors also promote neovascularization. The second category is based on scaffold technology, including natural biologically derived scaffolds and synthetic scaffolds. This review summarizes the research progress of tissue engineering vascularization strategy.